Immature T cell proliferation

pathway activity — cross-omics
GO:0033079Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Immature T cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALOX5, EHBP1L1, and LCP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMALOX5 →+0.467+0.051.009.00135
OVEHBP1L1 →+0.298+0.050.002<.00135
GBMLCP1 →+0.505+0.049.008.00435
OVARHGAP45 →+0.440+0.051<.001<.00135
OVARHGDIB →+0.528+0.057<.001<.00135
GBMPPP1R18_S368 →+0.523+0.073.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration