T cell differentiation in thymus

Across TCGA patient cohorts, RNA activity of the T cell differentiation in thymus pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP15, CCR7, and CSF2RB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell differentiation in thymus activity versus PARP15 in CCRCC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PARP15 →	+0.573	+0.707	.003	.009	3	7
BRCA	CCR7 →	+0.865	+0.715	.002	.006	3	6
GBM	CSF2RB →	+0.577	+0.552	<.001	.001	3	6
UCEC	STX11 →	+0.582	+0.919	<.001	.001	3	6
BRCA	ICOS →	+1.029	+0.971	<.001	<.001	3	6
BRCA	CARD17 →	+0.486	+0.738	.005	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033077 vs PARP15 — CCRCC

Explore this scatter interactively →