T cell differentiation in thymus

Across TCGA cell cohorts, RNA activity of the T cell differentiation in thymus pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOL3, PSMB10, and PLAAT4, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell differentiation in thymus activity versus APOL3 in LIVER (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	APOL3 →	+2.462	+0.131	<.001	.001	3	16
URINARY_TRACT	PSMB10 →	+1.285	+0.122	.001	.001	3	15
URINARY_TRACT	PLAAT4 →	+3.420	+0.126	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	UBE2L6 →	+2.323	+0.154	<.001	<.001	3	14
LIVER	PSMB9 →	+4.914	+0.180	<.001	<.001	3	14
SOFT_TISSUE	IFIT3 →	+3.035	+0.108	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033077 vs APOL3 — LIVER

Explore this scatter interactively →