T cell differentiation in thymus

Across TCGA cell cohorts, RNA activity of the T cell differentiation in thymus pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCK, NAA50, and MAP2K6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell differentiation in thymus activity versus DCK in SKIN (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DCK →	+0.522	+0.232	<.001	.001	3	6
LIVER	NAA50 →	+1.187	+0.292	.001	.001	3	5
BLOOD_Leukemia	MAP2K6 →	+1.443	+0.162	.002	.007	3	5
OESOPHAGUS	KIAA0232 →	+0.870	+0.265	<.001	.005	3	5
LARGE_INTESTINE	RFK →	+1.043	+0.302	<.001	<.001	3	5
LIVER	SFXN1 →	+0.844	+0.211	.003	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033077 vs DCK — SKIN

Explore this scatter interactively →