Cellular pigmentation

Across TCGA patient cohorts, RNA activity of the Cellular pigmentation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DAP3, MRPS35, and SERPINB8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular pigmentation activity versus DAP3 in COAD (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DAP3 →	-0.355	-0.027	<.001	<.001	3	7
COAD	MRPS35 →	-0.403	-0.026	<.001	<.001	3	7
OV	SERPINB8 →	+0.561	+0.030	.004	.004	3	6
OV	MAP9_S79 →	+1.044	+0.039	<.001	<.001	3	6
COAD	MRPS31 →	-0.414	-0.024	<.001	<.001	3	6
COAD	MRPS9 →	-0.333	-0.019	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033059 vs DAP3 — COAD

Explore this scatter interactively →