Cellular pigmentation

Across TCGA cell cohorts, RNA activity of the Cellular pigmentation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD12, ATP6V1E1, and RPL22L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular pigmentation activity versus ABHD12 in CNS (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ABHD12 →	+0.934	+0.188	<.001	.002	3	3
SKIN	ATP6V1E1 →	+0.693	+0.275	.007	.005	3	3
SKIN	RPL22L1 →	-1.559	-0.303	<.001	.001	3	3
SKIN	PCYT2 →	+1.153	+0.350	<.001	<.001	3	3
SKIN	NEU1 →	+1.073	+0.248	.002	.002	3	3
SKIN	ST3GAL6 →	+2.420	+0.306	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033059 vs ABHD12 — CNS

Explore this scatter interactively →