Regulation of mitotic sister chromatid segregation

Across TCGA cell cohorts, RNA activity of the Regulation of mitotic sister chromatid segregation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZCWPW2, HUS1, and KIF14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZCWPW2 grouped by Regulation of mitotic sister chromatid segregation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZCWPW2 →	-0.348	-0.232	<.001	<.001	3	4
LIVER	HUS1 →	+0.789	+0.234	.008	.003	3	4
LUNG_NSCLC_LUAD	KIF14 →	-0.502	-0.117	.004	.002	3	4
LUNG_NSCLC_LUAD	TBCE →	-0.516	-0.142	.004	.003	3	4
BONE	NSUN7 →	+1.978	+0.249	<.001	.001	3	4
URINARY_TRACT	OAZ2 →	-1.091	-0.203	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZCWPW2 by Regulation of mitotic sister chromatid segregation activity — URINARY_TRACT

Explore this box plot interactively →