Regulation of mitotic sister chromatid segregation

Across TCGA cell cohorts, RNA activity of the Regulation of mitotic sister chromatid segregation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRXL2C, BABAM2, and ZDHHC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitotic sister chromatid segregation activity versus PRXL2C in BLOOD_Leukemia (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRXL2C →	-1.120	-0.103	.003	.008	3	5
BLOOD_Lymphoma	BABAM2 →	-0.988	-0.166	<.001	<.001	3	5
LUNG_NSCLC_LUSC	ZDHHC2 →	-1.364	-0.249	.001	.007	3	4
BONE	FARP1 →	+1.394	+0.139	.004	.008	3	4
PANCREAS	SLC6A8 →	-1.756	-0.232	<.001	<.001	3	4
BLOOD_Lymphoma	TMEM35B →	-1.125	-0.131	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033047 vs PRXL2C — BLOOD_Leukemia

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