Regulation of sister chromatid segregation

Across TCGA cell cohorts, RNA activity of the Regulation of sister chromatid segregation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCK2, TSEN15, and CKS1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UCK2 grouped by Regulation of sister chromatid segregation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	UCK2 →	-0.639	-0.100	.001	.006	3	5
STOMACH	TSEN15 →	-0.892	-0.187	.004	.002	3	4
LUNG_NSCLC_LUAD	CKS1B →	-0.652	-0.111	.006	<.001	2	5
BREAST	TMEM175 →	+0.932	+0.124	<.001	<.001	2	5
BREAST	JOSD2 →	+0.810	+0.096	.001	.004	3	4
STOMACH	ZNF862 →	+1.554	+0.226	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UCK2 by Regulation of sister chromatid segregation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →