Regulation of sister chromatid segregation

Across TCGA cell cohorts, RNA activity of the Regulation of sister chromatid segregation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED3, GSTM4, and PABPN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sister chromatid segregation activity versus TMED3 in STOMACH (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TMED3 →	-1.240	-1.016	.006	.008	3	6
KIDNEY	GSTM4 →	-2.053	-1.055	.003	<.001	3	5
OESOPHAGUS	PABPN1 →	+0.719	+0.117	.001	.008	3	5
OESOPHAGUS	PPP1R3E →	+1.194	+0.110	.001	.004	3	5
BLOOD_Lymphoma	S100A6 →	-3.971	-0.145	.003	.007	3	5
BLOOD_Lymphoma	GPC2 →	+1.871	+0.151	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033045 vs TMED3 — STOMACH

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