Regulation of chromosome organization

Across TCGA cell cohorts, RNA activity of the Regulation of chromosome organization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC15, TUBA1A, and ADAMTSL4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chromosome organization activity versus DNAJC15 in URINARY_TRACT (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DNAJC15 →	-2.278	-0.125	.006	<.001	3	6
BLOOD_Leukemia	TUBA1A →	+1.345	+0.076	<.001	.002	3	6
BLOOD_Leukemia	ADAMTSL4 →	-2.343	-0.099	<.001	<.001	3	5
BLOOD_Leukemia	MEX3A →	+1.747	+0.099	<.001	.007	3	5
BLOOD_Leukemia	CCL5 →	-2.499	-0.081	<.001	.001	3	5
LIVER	ATP6AP1 →	-1.394	-0.118	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033044 vs DNAJC15 — URINARY_TRACT

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