Positive regulation of myeloid cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of myeloid cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPS15, MYCBP2, and MEF2C, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid cell apoptotic process activity versus EPS15 in UVM (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	EPS15 →	+1.217	+0.074	<.001	<.001	3	29
UVM	MYCBP2 →	+1.027	+0.076	<.001	<.001	3	28
LAML	MEF2C →	+1.178	+0.064	<.001	<.001	3	28
DLBC	RIC1 →	+1.171	+0.074	.003	.003	1	29
THYM	ELK3 →	+1.121	+0.049	<.001	<.001	3	27
THYM	PLSCR4 →	+1.797	+0.052	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033034 vs EPS15 — UVM

Explore this scatter interactively →