Positive regulation of myeloid cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of myeloid cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WAS, DOCK8, and ARHGAP45, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid cell apoptotic process activity versus WAS in HNSC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	WAS →	+0.479	+0.067	<.001	<.001	3	10
LSCC	DOCK8 →	+0.527	+0.098	<.001	<.001	3	10
GBM	ARHGAP45 →	+0.546	+0.082	<.001	<.001	3	10
LSCC	THEMIS2 →	+0.509	+0.099	<.001	<.001	3	9
GBM	TNFAIP8L2 →	+0.492	+0.061	<.001	<.001	3	9
OV	ENTPD1 →	+0.480	+0.070	.002	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033034 vs WAS — HNSC

Explore this scatter interactively →