Positive regulation of myeloid cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of myeloid cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTM1, LPAR3, and UBE2E3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid cell apoptotic process activity versus MTM1 in OV (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MTM1 →	-0.607	-0.765	<.001	<.001	3	3
OV	LPAR3 →	-1.392	-0.545	.001	.007	3	3
PDAC	UBE2E3 →	-0.260	-0.732	.009	.005	2	4
PDAC	COL15A1 →	+0.410	+0.673	<.001	.001	3	3
BRCA	RANGRF →	+0.314	+0.633	.005	.005	3	3
BRCA	SPTSSA →	-0.447	-0.614	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033034 vs MTM1 — OV

Explore this scatter interactively →