Positive regulation of myeloid cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of myeloid cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPAG1, FAM167B, and ATP8B1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPAG1 grouped by Positive regulation of myeloid cell apoptotic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SPAG1 →	-1.099	-0.900	.002	.004	3	4
LIVER	FAM167B →	+0.910	+1.832	.009	<.001	3	4
LUNG_SCLC	ATP8B1 →	+2.248	+1.227	<.001	.001	3	3
LUNG_NSCLC_LUAD	ITGB8 →	+1.128	+0.610	.006	.004	3	3
KIDNEY	STC1 →	+2.800	+1.496	<.001	.004	3	3
KIDNEY	DCTN5 →	-0.948	-1.488	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPAG1 by Positive regulation of myeloid cell apoptotic process activity — PANCREAS

Explore this box plot interactively →