Positive regulation of myeloid cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of myeloid cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGLN3, DDA1, and BEST4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myeloid cell apoptotic process activity versus EGLN3 in LUNG_NSCLC_LUAD (Pearson r = -0.98).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EGLN3 →	-3.310	-0.358	.008	.007	3	3
BONE	DDA1 →	+1.173	+0.577	.005	<.001	3	3
BONE	BEST4 →	-0.099	-0.577	.004	<.001	3	3
LARGE_INTESTINE	MINPP1 →	+0.886	+0.400	.008	.001	3	3
LARGE_INTESTINE	RPL7L1 →	+0.714	+0.400	.006	.001	3	3
BLOOD_Lymphoma	CXCR2 →	-0.210	-1.850	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033034 vs EGLN3 — LUNG_NSCLC_LUAD

Explore this scatter interactively →