Negative regulation of myeloid cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of myeloid cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM7A, CCN1, and LRRK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KDM7A grouped by Negative regulation of myeloid cell apoptotic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KDM7A →	-2.009	-1.180	<.001	.001	3	5
URINARY_TRACT	CCN1 →	+2.676	+1.792	.001	<.001	3	5
SOFT_TISSUE	LRRK1 →	+2.230	+1.264	.001	.003	3	5
LUNG_NSCLC_LUSC	FMNL1 →	+2.640	+1.082	<.001	.002	3	5
URINARY_TRACT	MYL6B →	+1.114	+1.915	.007	<.001	3	4
OVARY	NDUFB7 →	+0.524	+1.256	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KDM7A by Negative regulation of myeloid cell apoptotic process activity — STOMACH

Explore this box plot interactively →