Regulation of myeloid cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of myeloid cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, TBC1D2B, and STK10, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myeloid cell apoptotic process activity versus RCSD1 in UCEC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCSD1 →	+0.650	+0.081	<.001	<.001	3	10
GBM	TBC1D2B →	+0.301	+0.088	<.001	<.001	3	10
UCEC	STK10 →	+0.459	+0.072	<.001	<.001	3	10
GBM	CD14 →	+0.529	+0.061	<.001	<.001	3	10
OV	DOCK10 →	+0.450	+0.062	<.001	<.001	3	10
UCEC	DOCK2 →	+0.603	+0.061	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033032 vs RCSD1 — UCEC

Explore this scatter interactively →