Regulation of myeloid cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of myeloid cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, FAS, and EIF2AK4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myeloid cell apoptotic process activity versus ANXA1 in SKIN (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ANXA1 →	+3.580	+0.343	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	FAS →	+1.138	+0.164	<.001	.008	2	7
BREAST	EIF2AK4 →	+0.824	+0.398	<.001	<.001	3	6
LUNG_SCLC	SLC25A12 →	+0.877	+0.327	<.001	<.001	3	6
BLOOD_Myeloma	CPNE7 →	+3.669	+0.284	<.001	.003	3	5
BLOOD_Myeloma	FKBP1A →	+0.944	+0.231	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033032 vs ANXA1 — SKIN

Explore this scatter interactively →