Myeloid cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Myeloid cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRPV4, CAMSAP3, and MEDAG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid cell apoptotic process activity versus TRPV4 in GBM (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRPV4 →	+0.529	+0.278	.001	<.001	3	4
GBM	CAMSAP3 →	-0.793	-0.222	<.001	<.001	3	4
GBM	MEDAG →	+0.809	+0.221	.002	<.001	3	3
UCEC	KLF4 →	+0.651	+0.173	.009	.006	3	3
GBM	P2RY8 →	+0.576	+0.195	.003	.001	3	3
BRCA	ELOA-AS1 →	-0.227	-0.231	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033028 vs TRPV4 — GBM

Explore this scatter interactively →