Myeloid cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Myeloid cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNTNAP1, TRPC1, and SPATA24, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNTNAP1 grouped by Myeloid cell apoptotic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CNTNAP1 →	+1.159	+0.610	.006	.005	3	4
BREAST	TRPC1 →	+0.780	+0.437	.008	.006	2	5
BREAST	SPATA24 →	+0.732	+0.791	.003	.003	3	4
SKIN	JADE3 →	-0.555	-0.840	.003	.009	3	3
SKIN	PPM1L →	-0.650	-0.936	.002	.009	3	3
SKIN	ACOX2 →	+1.832	+1.016	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNTNAP1 by Myeloid cell apoptotic process activity — BREAST

Explore this box plot interactively →