Myeloid cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Myeloid cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFNB2, RSPH6A, and CTSL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid cell apoptotic process activity versus EFNB2 in OESOPHAGUS (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EFNB2 →	-3.170	-0.432	.003	.009	2	5
BONE	RSPH6A →	+0.033	+1.233	<.001	.007	3	4
SKIN	CTSL →	+1.369	+1.167	.001	<.001	3	4
LUNG_SCLC	IMPG2 →	+0.216	+0.345	.007	.005	3	3
BREAST	MYL12A →	+1.529	+1.102	<.001	.002	3	3
BREAST	ADAM9 →	+2.629	+1.511	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033028 vs EFNB2 — OESOPHAGUS

Explore this scatter interactively →