Tetrapyrrole catabolic process

Across TCGA cell cohorts, RNA activity of the Tetrapyrrole catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM243, PDE4B, and PAK5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM243 grouped by Tetrapyrrole catabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TMEM243 →	-0.256	-0.198	<.001	.005	3	5
URINARY_TRACT	PDE4B →	+0.165	+0.270	.004	.007	3	4
LARGE_INTESTINE	PAK5 →	+0.239	+0.173	.005	.007	3	4
LARGE_INTESTINE	RRAS →	-0.141	-0.203	<.001	<.001	3	4
STOMACH	DAZL →	+0.160	+0.154	<.001	<.001	3	4
SOFT_TISSUE	PROX1 →	+0.181	+0.212	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM243 by Tetrapyrrole catabolic process activity — LUNG_SCLC

Explore this box plot interactively →