Tetrapyrrole biosynthetic process

Across TCGA patient cohorts, RNA activity of the Tetrapyrrole biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC16A_S595, SLC4A1_S356, and SYF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrapyrrole biosynthetic process activity versus SEC16A_S595 in LUAD (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SEC16A_S595 →	+0.396	+0.181	.005	.001	3	3
CCRCC	SLC4A1_S356 →	+1.599	+0.199	<.001	<.001	3	3
GBM	SYF2 →	-0.355	-0.142	<.001	<.001	3	3
BRCA	UBAC1_S98 →	+0.563	+0.129	<.001	<.001	3	3
OV	ZNF687_S1191 →	-0.562	-0.147	<.001	.001	3	3
COAD	ABCB10 →	+0.383	+0.205	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033014 vs SEC16A_S595 — LUAD

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