Tetrapyrrole metabolic process

Across TCGA patient cohorts, RNA activity of the Tetrapyrrole metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLGAP5, CSE1L, and FBXO5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrapyrrole metabolic process activity versus DLGAP5 in UCEC (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DLGAP5 →	-0.789	-0.165	.001	<.001	3	7
UCEC	CSE1L →	-0.692	-0.241	<.001	<.001	3	6
GBM	FBXO5 →	-0.721	-0.164	<.001	<.001	3	6
UCEC	CDC6 →	-0.872	-0.207	.003	.003	3	6
OV	VRK1 →	-0.566	-0.142	.001	<.001	3	5
UCEC	CENPA →	-1.192	-0.301	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033013 vs DLGAP5 — UCEC

Explore this scatter interactively →