Tetrapyrrole metabolic process

Across TCGA cell cohorts, RNA activity of the Tetrapyrrole metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARD8, AGBL5, and RTN4R, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CARD8 grouped by Tetrapyrrole metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CARD8 →	-0.655	-0.995	.006	.005	3	4
CNS	AGBL5 →	+0.546	+1.017	.001	.003	3	4
LUNG_NSCLC_LUSC	RTN4R →	+1.277	+1.289	<.001	<.001	3	4
LARGE_INTESTINE	AHNAK2 →	-2.379	-0.798	<.001	.001	3	4
LUNG_NSCLC_LUAD	MAP7 →	+1.900	+0.728	<.001	.009	3	4
PANCREAS	THADA →	+0.610	+1.119	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CARD8 by Tetrapyrrole metabolic process activity — SKIN

Explore this box plot interactively →