Negative regulation of mast cell activation involved in immune response

pathway activity — cross-omics
GO:0033007Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Negative regulation of mast cell activation involved in immune response pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYBB, ITGAL, and LCP2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mast cell activation involved in immune response activity versus CYBB in GBM (Pearson r = 0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMCYBB →+0.674+0.106<.001<.00139
UCECITGAL →+0.622+0.096<.001<.00139
GBMLCP2 →+0.519+0.127<.001<.00139
GBMAPBB1IP →+0.609+0.139<.001<.00139
GBMPLCB2 →+0.583+0.125<.001<.00139
UCECPSMB10 →+0.509+0.076<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033007 vs CYBB — GBM

Per-sample scatter of Negative regulation of mast cell activation involved in immune response activity vs CYBB in GBM.

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Exploration