Negative regulation of mast cell activation involved in immune response

Across TCGA patient cohorts, RNA activity of the Negative regulation of mast cell activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDCA7L, MSH2, and MRPL19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mast cell activation involved in immune response activity versus CDCA7L in BRCA (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDCA7L →	-1.197	-0.742	<.001	<.001	3	5
BRCA	MSH2 →	-0.414	-0.477	.009	.003	3	4
BRCA	MRPL19 →	-0.495	-0.365	<.001	.009	3	3
BRCA	NLN →	-0.475	-0.456	<.001	<.001	3	3
BRCA	CENPO →	-0.485	-0.456	.003	.006	3	3
BRCA	BARD1 →	-0.426	-0.323	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033007 vs CDCA7L — BRCA

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