Negative regulation of mast cell activation involved in immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of mast cell activation involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNTNAP1, SCARF2, and CLIP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNTNAP1 grouped by Negative regulation of mast cell activation involved in immune response-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CNTNAP1 →	-1.175	-1.085	.004	<.001	3	5
STOMACH	SCARF2 →	-1.981	-1.384	.004	.001	3	4
CNS	CLIP3 →	-1.450	-1.108	.001	<.001	3	4
BLOOD_Leukemia	TBL2 →	+0.707	+1.148	.003	.007	3	4
LUNG_SCLC	ZSCAN18 →	-2.161	-0.982	.002	.003	3	4
BREAST	PRSS27 →	+1.171	+0.986	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNTNAP1 by Negative regulation of mast cell activation involved in immune response activity — CNS

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