Negative regulation of mast cell activation

Across TCGA patient cohorts, RNA activity of the Negative regulation of mast cell activation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SKAP2, TRIM21, and WDFY4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mast cell activation activity versus SKAP2 in GBM (Pearson r = 0.83).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SKAP2 →	+0.842	+0.139	<.001	<.001	3	9
GBM	TRIM21 →	+0.510	+0.137	<.001	<.001	3	9
GBM	WDFY4 →	+0.522	+0.149	<.001	<.001	3	9
GBM	BTK →	+0.616	+0.161	<.001	<.001	3	9
HNSC	CASP4 →	+0.567	+0.076	<.001	<.001	3	9
GBM	HCK →	+0.891	+0.155	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033004 vs SKAP2 — GBM

Explore this scatter interactively →