Negative regulation of mast cell activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of mast cell activation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP51A1, PTMA, and CFAP20, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP51A1 grouped by Negative regulation of mast cell activation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CYP51A1 →	+1.780	+1.151	.004	.001	3	4
OVARY	PTMA →	+0.445	+1.063	.002	.008	3	4
KIDNEY	CFAP20 →	+0.725	+1.363	.005	<.001	3	4
LUNG_NSCLC_LUAD	PHGDH →	+2.384	+0.838	<.001	.004	3	4
LUNG_SCLC	ZBTB22 →	-0.805	-1.172	.001	<.001	3	3
BREAST	TUBGCP3 →	+0.566	+0.701	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP51A1 by Negative regulation of mast cell activation activity — STOMACH

Explore this box plot interactively →