Negative regulation of mast cell activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of mast cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PBX4, PES1, and TOMM22, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mast cell activation activity versus PBX4 in BLOOD_Leukemia (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PBX4 →	-0.984	-1.207	.007	.003	3	2
BLOOD_Lymphoma	PES1 →	+0.986	+1.913	<.001	<.001	3	1
BLOOD_Lymphoma	TOMM22 →	+0.820	+1.784	.002	<.001	3	1
BLOOD_Lymphoma	C14orf93 →	-0.462	-1.546	.001	.004	3	1
BLOOD_Lymphoma	SPOCK2 →	+1.317	+1.562	.003	.005	3	1
BLOOD_Lymphoma	NUP214 →	+0.894	+1.532	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033004 vs PBX4 — BLOOD_Leukemia

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