Regulation of mast cell activation

Across TCGA patient cohorts, RNA activity of the Regulation of mast cell activation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCIMP, LST1, and CCR5AS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mast cell activation activity versus SCIMP in CCRCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SCIMP →	+0.379	+0.170	.002	.009	3	4
GBM	LST1 →	+0.689	+0.195	.001	.004	3	4
GBM	CCR5AS →	+0.411	+0.125	.005	.007	3	4
COAD	SLC25A13 →	-0.239	-0.236	.008	.003	3	3
LSCC	FBXO31 →	-0.289	-0.683	.009	.001	3	3
LSCC	DUSP5P1 →	-0.587	-0.556	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033003 vs SCIMP — CCRCC

Explore this scatter interactively →