Regulation of mast cell activation

Across TCGA cell cohorts, RNA activity of the Regulation of mast cell activation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HTATIP2, GID8, and GBE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HTATIP2 grouped by Regulation of mast cell activation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	HTATIP2 →	-4.198	-1.938	.007	<.001	3	4
PANCREAS	GID8 →	+0.496	+0.858	.008	.006	3	4
KIDNEY	GBE1 →	-1.020	-1.147	.001	.002	3	4
STOMACH	HELLS →	+0.891	+1.221	.004	.002	3	3
STOMACH	STARD7 →	+0.587	+1.354	<.001	<.001	3	3
OVARY	ETV7 →	+0.611	+1.001	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HTATIP2 by Regulation of mast cell activation activity — LIVER

Explore this box plot interactively →