Protein-RNA complex disassembly

Across TCGA patient cohorts, RNA activity of the Protein-RNA complex disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMCO1, HSPH1_S809, and MRPL35, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-RNA complex disassembly activity versus TMCO1 in CCRCC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TMCO1 →	-0.504	-0.040	<.001	<.001	3	5
COAD	HSPH1_S809 →	-0.341	-0.017	.004	.004	3	5
COAD	MRPL35 →	-0.263	-0.023	.003	.001	2	6
LUAD	TP53BP1 →	+0.211	+0.034	.002	.003	3	5
BRCA	COL3A1 →	+0.646	+0.024	<.001	.003	3	5
BRCA	ENAH →	+0.251	+0.020	.004	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032988 vs TMCO1 — CCRCC

Explore this scatter interactively →