Protein-RNA complex disassembly

Across TCGA cell cohorts, RNA activity of the Protein-RNA complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLC1, TTC7B, and SH3YL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-RNA complex disassembly activity versus KLC1 in BONE (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	KLC1 →	+0.823	+0.239	.006	.002	3	6
STOMACH	TTC7B →	+2.638	+0.191	<.001	.002	3	6
PANCREAS	SH3YL1 →	-1.838	-0.224	.001	.007	3	6
STOMACH	APBB1 →	+3.013	+0.233	<.001	.002	3	6
SKIN	FSTL1 →	+2.772	+0.259	<.001	<.001	3	5
BONE	AKT1 →	+1.274	+0.291	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032988 vs KLC1 — BONE

Explore this scatter interactively →