Protein-containing complex disassembly

Across TCGA cell cohorts, RNA activity of the Protein-containing complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF14, DUSP8, and SH2B3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF14 grouped by Protein-containing complex disassembly-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KIF14 →	-1.091	-0.222	<.001	.002	3	6
STOMACH	DUSP8 →	+1.364	+0.141	.005	<.001	3	4
LARGE_INTESTINE	SH2B3 →	-1.108	-0.099	.002	.004	3	4
LARGE_INTESTINE	PRPS1 →	-0.795	-0.123	.003	<.001	2	5
LARGE_INTESTINE	EME1 →	-0.622	-0.126	.004	.008	2	5
LUNG_SCLC	ZFAND5 →	+0.913	+0.153	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF14 by Protein-containing complex disassembly activity — PANCREAS

Explore this box plot interactively →