Protein-containing complex disassembly

Across TCGA cell cohorts, RNA activity of the Protein-containing complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF126, LSM12, and POLDIP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-containing complex disassembly activity versus RNF126 in SOFT_TISSUE (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RNF126 →	+0.821	+0.261	.004	.004	3	7
PANCREAS	LSM12 →	+0.917	+0.366	<.001	<.001	3	7
PANCREAS	POLDIP2 →	+0.778	+0.342	.001	<.001	3	7
OVARY	MRPL16 →	+0.622	+0.238	.005	.004	3	6
OVARY	KHSRP →	+0.927	+0.249	<.001	<.001	3	6
PANCREAS	SRSF9 →	+0.743	+0.234	.002	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032984 vs RNF126 — SOFT_TISSUE

Explore this scatter interactively →