Collagen biosynthetic process

Across TCGA cell cohorts, RNA activity of the Collagen biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL12A1, LOXL2, and BRI3BP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collagen biosynthetic process activity versus COL12A1 in BONE (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	COL12A1 →	+5.923	+1.751	.001	.009	3	6
BREAST	LOXL2 →	+3.879	+1.251	.001	.002	3	6
BREAST	BRI3BP →	-1.145	-1.145	<.001	.001	3	6
LUNG_NSCLC_LUSC	VEGFC →	+3.941	+2.266	.004	<.001	3	6
CNS	TAGLN →	+3.171	+0.463	.008	.003	3	6
BREAST	GLIPR1 →	+2.587	+1.206	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032964 vs COL12A1 — BONE

Explore this scatter interactively →