Collagen metabolic process

Across TCGA patient cohorts, RNA activity of the Collagen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPARC, PRRX1, and CCN2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collagen metabolic process activity versus SPARC in BRCA (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPARC →	+1.332	+0.329	<.001	<.001	3	10
HNSC	PRRX1 →	+1.241	+0.297	<.001	<.001	3	10
OV	CCN2 →	+1.559	+0.408	<.001	<.001	3	10
UCEC	TSHZ3 →	+0.904	+0.247	.002	<.001	3	10
BRCA	TGFB1I1 →	+1.124	+0.293	<.001	<.001	3	10
OV	OLFML2B →	+1.221	+0.333	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032963 vs SPARC — BRCA

Explore this scatter interactively →