Collagen metabolic process

Across TCGA cell cohorts, RNA activity of the Collagen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STKLD1, ULK1, and NPIPB6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STKLD1 grouped by Collagen metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	STKLD1 →	+0.705	+1.061	<.001	<.001	3	4
PANCREAS	ULK1 →	+1.126	+1.220	.003	<.001	3	4
OVARY	NPIPB6 →	+0.548	+1.528	<.001	<.001	3	4
PANCREAS	NCOA2 →	+0.746	+1.309	.002	<.001	3	4
BLOOD_Lymphoma	GRHL1 →	+1.299	+1.918	.001	<.001	3	4
BLOOD_Lymphoma	TMEM86A →	+0.929	+2.041	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STKLD1 by Collagen metabolic process activity — BREAST

Explore this box plot interactively →