Collagen metabolic process

Across TCGA cell cohorts, RNA activity of the Collagen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P3H1, LOXL2, and HTRA1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collagen metabolic process activity versus P3H1 in BREAST (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	P3H1 →	+1.979	+0.787	<.001	.001	3	8
LUNG_NSCLC_LUAD	LOXL2 →	+2.991	+0.358	<.001	<.001	3	8
BONE	HTRA1 →	+4.270	+1.382	.002	.009	3	7
LUNG_NSCLC_LUSC	CRTAP →	+2.520	+0.623	.001	.006	3	7
BREAST	MAP4 →	+1.056	+0.853	<.001	.001	3	7
OVARY	TBC1D30 →	-1.155	-0.197	<.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032963 vs P3H1 — BREAST

Explore this scatter interactively →