Positive regulation of inositol trisphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of inositol trisphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAG6, DPM2, and TSEN15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BAG6 grouped by Positive regulation of inositol trisphosphate biosynthetic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	BAG6 →	+0.705	+1.625	.001	<.001	3	4
PANCREAS	DPM2 →	+0.568	+0.800	.003	.009	3	4
BLOOD_Myeloma	TSEN15 →	-1.256	-1.302	<.001	.003	3	4
BLOOD_Lymphoma	KLRG1 →	+2.023	+2.216	<.001	<.001	3	4
BONE	ABHD4 →	-1.311	-1.561	.001	.001	3	3
BONE	DLST →	-0.653	-1.972	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAG6 by Positive regulation of inositol trisphosphate biosynthetic process activity — KIDNEY

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