Positive regulation of inositol trisphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of inositol trisphosphate biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAAF5, SIGLEC9, and KCND1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAAF5 grouped by Positive regulation of inositol trisphosphate biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DNAAF5 →	+0.166	+1.362	.001	<.001	3	4
BLOOD_Lymphoma	SIGLEC9 →	+0.192	+2.189	.007	<.001	3	4
BLOOD_Myeloma	KCND1 →	+0.226	+1.317	.001	.001	3	3
BLOOD_Myeloma	ADCY3 →	-0.300	-1.628	.006	.003	3	3
LIVER	PCGF1 →	+0.162	+1.054	.002	.005	3	3
SKIN	TRIM39 →	+0.175	+0.141	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAAF5 by Positive regulation of inositol trisphosphate biosynthetic process activity — BREAST

Explore this box plot interactively →