Regulation of inositol trisphosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of inositol trisphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PBX4, IQCD, and FER1L4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of inositol trisphosphate biosynthetic process activity versus PBX4 in LSCC (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PBX4 →	-0.492	-0.927	.003	<.001	3	3
UCEC	IQCD →	-0.702	-0.788	<.001	<.001	3	3
LSCC	FER1L4 →	-0.610	-0.635	<.001	.001	3	3
GBM	LARP4B →	-0.364	-0.981	<.001	<.001	3	3
COAD	WDR77 →	-0.372	-0.288	.004	<.001	3	2
COAD	EIF3H →	-0.332	-0.346	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032960 vs PBX4 — LSCC

Explore this scatter interactively →