Regulation of inositol trisphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of inositol trisphosphate biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTK2B, GPER1, and P2RY6, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTK2B grouped by Regulation of inositol trisphosphate biosynthetic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PTK2B →	-0.226	-1.425	.002	<.001	3	11
BLOOD_Leukemia	GPER1 →	-0.204	-1.235	.004	<.001	3	9
OESOPHAGUS	P2RY6 →	-0.216	-1.288	.001	.001	3	8
LUNG_NSCLC_LUSC	LHCGR →	-0.244	-1.598	<.001	.003	2	9
KIDNEY	P2RY1 →	-0.216	-1.087	.002	.001	3	8
STOMACH	GNE →	-0.208	-1.189	.004	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTK2B by Regulation of inositol trisphosphate biosynthetic process activity — SKIN

Explore this box plot interactively →