Inositol phosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Inositol phosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDI1, CEACAM21, and NME3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GDI1 grouped by Inositol phosphate biosynthetic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GDI1 →	-1.006	-1.788	.003	<.001	3	4
BLOOD_Lymphoma	CEACAM21 →	+2.183	+1.751	.002	<.001	3	4
LUNG_NSCLC_LUAD	NME3 →	-1.206	-1.231	.007	<.001	3	4
BLOOD_Leukemia	AASS →	+1.935	+0.877	.001	.008	3	4
LIVER	AOC2 →	-0.773	-1.648	.003	<.001	3	4
BLOOD_Lymphoma	CAMSAP1 →	-1.114	-1.859	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GDI1 by Inositol phosphate biosynthetic process activity — BLOOD_Lymphoma

Explore this box plot interactively →