Inositol trisphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Inositol trisphosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGB2, CCM2, and RCSD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inositol trisphosphate metabolic process activity versus ITGB2 in GBM (Pearson r = -0.00).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ITGB2 →	+0.618	+0.091	<.001	<.001	3	7
LSCC	CCM2 →	+0.223	+0.066	.004	<.001	3	7
UCEC	RCSD1 →	+0.610	+0.076	<.001	.003	3	6
OV	RGS19 →	+0.347	+0.041	.002	.002	3	6
GBM	SIPA1 →	+0.307	+0.070	<.001	<.001	3	6
GBM	SKAP2 →	+0.695	+0.077	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032957 vs ITGB2 — GBM

Explore this scatter interactively →