Inositol trisphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Inositol trisphosphate metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P2RY1, PTK2B, and LHCGR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, P2RY1 grouped by Inositol trisphosphate metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	P2RY1 →	-0.227	-0.999	.001	.006	3	6
LIVER	PTK2B →	-0.228	-1.102	.001	<.001	3	6
LUNG_NSCLC_LUAD	LHCGR →	-0.121	-0.791	<.001	.003	3	5
SOFT_TISSUE	GJC3 →	-0.313	-1.264	.003	.002	3	5
LUNG_NSCLC_LUSC	PLCG2 →	-0.253	-1.246	.006	<.001	3	5
OVARY	PPP1R12A →	-0.322	-0.892	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P2RY1 by Inositol trisphosphate metabolic process activity — CNS

Explore this box plot interactively →