Inositol trisphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Inositol trisphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR17, IMMP2L, and EHD4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR17 grouped by Inositol trisphosphate metabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	WDR17 →	+1.468	+1.517	.008	.004	3	4
BLOOD_Myeloma	IMMP2L →	+1.157	+1.949	.003	<.001	3	4
BONE	EHD4 →	-2.130	-1.859	.002	<.001	3	4
BLOOD_Myeloma	MAPK13 →	-3.202	-1.894	.001	<.001	2	4
SOFT_TISSUE	REEP4 →	-0.724	-1.116	.004	.005	3	3
PANCREAS	OGT →	+1.239	+1.619	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR17 by Inositol trisphosphate metabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →